Thursday, July 5, 2007

JULY 3rd, 2007


TUESDAY July 3rd, 2007

Two Follicles
Today we had another visit with Dr. Parikh. Now two follicles, and four more days of Menogon. I am really getting tired of being stuck with a big, fat needle twice a day! All this for two follicles. Wondertwins divide! We are keeping our hopes up, and have gone over the contract we will be signing, changing a few crucial details, like removing the sentence that gives the Surrogate the right to terminate for non-health reasons, and conversely inserting a line that gives us the right to terminate if, upon genetic testing- which would happen with amnio- the fetus is found to be abnormal. I got the feeling from the very informal forms, that Surrogacy actually happens rather infrequently. Or maybe this is a hallmark of the more relaxed legal situation (and less legal expense) that was a factor in our decision to come here. Dr Parikh has continued to remind us that all we need is one embryo to implant, but I do know enough about the process to know that older eggs are less likely to fertilize properly, and more likely to miscarry if they do implant. Not the best of news! But, we remind ourselves, this is why we are doing this here, so that we might try this more quickly and more inexpensively. Realistically, our odds in the states would be exactly the same in that we would have had the same number of follicles. And since one cannot just sit and wait, everyday we have been exploring new parts of the city. Yesterday in the morning we decided to go to the fabled Fabric Market. Indian fabrics are famously beautiful and exported all over the world, and I like the fact that India actually started to grow cotton to supply the British mills when American cotton production was disabled during the Civil War, another crazy-little-world outsource story. When we first stepped out of the cab at the general market we were met by a taut- I believe he was Muslim because he was wearing a round white cap, and a long white flowing rope that zipped up the front. He directed us up some crazy narrow stairs to his designated store, which didn't have what we are looking for- material to re-cover my Grandmother's dining chairs- but I did buy a pillow cover out of sympathy, and he did learn what it was we were looking for. Next he took us across the street (and again up the stairs) to an upholstery fabric shop which had almost the right fabric. I think when he had run out of “his stores”, or realized we were going to be tough customers, he raised his hands in “sorry”, so we gave him a Rs100 bill ($2.50) and were off. And so we went to find the Mangaldas Market, and, after several more tauts and wrong directions, we stepped inside its narrow opening. It was exactly as I'd seen in Victorian Odalisque Bazaar etchings. The market is a two-story enclosed building about a square block big, full of cubbies on the ground floor about eight or ten feet square with narrow futons, meticulously covered in clean white cloth, spread on the floor, and bolt after bolt of fabric crammed into nooks on the sides, and piled in a small backroom with a curling staircase that allows access to the loft- presumably where the rest of the fabrics are kept. In the middle of the stall sit two of three men, cross-legged, with several younger men hovering- standing – in the back or in the aisle. The man in charge will ask what you want, “Miss” or “Madam” in my case. Fortunately, we had some swatches from the first store as a beginning point. And then out tumbled the fabric. After about five stalls in heat so pervasive and stifling, that time was marked by the beads of sweat that ran down my back- and not a Coke in sight- we decided we had better come another time when we could spend more time and were better hydrated, and headed back to the Hotel to get ready to see the Doctor. At night we went to Lower Patel and the Big Bazaar to one of the only Sports Bars in town. A “big” cricket match between Pakistan and India was being played in Glasgow and it sounded like it would be a fun cultural experience. Big Bazaar turned out to be a large shopping mall with a Marks and Spencer (British dept store), Lacoste, and lots of other Western stores. A lot like the Beverly Center. We went to The Bowling Co.- yes, the people there were bowling- we played some video games (Fast and Furious anyone?) and then went to the bar to wait for the match to start. Unfortunately, the game was called due to rain, but we hung around, drank a couple of happy-hour 2 for 1 beers, and watched as the room filled with young well-to-do people on their way home from work. Bombay has so many different hierarchies of wealth and education, just like LA, but everyone seems like they are relatively happy. It seems every corner is a jumping off point for an outrageous story or a common one. One of our favorite things to do is to look out from our window at the hotel, (a pigeons-eye view from the eighth floor), at any hour and watch the tiny dramas unfold, rush and pulse on our street. The other day, a woman spilled a bag of flour from off the top of her head all over the sidewalk on the other side of the street. As she knelt to scoop into a bag all that she could save, almost every passer-by either helped her or shook their head, undoubtedly telling her that what she was doing was unsanitary. Along came a woman whose cow tried to eat some of the flour, and even the corner’s resident dog came out from his storefront to take a look. Then, when she was almost done (woe be it to the people that get the dish made with that!) a car backed up through the driveway, and the drama was over.



Tuesday, July 3, 2007

JULY 2nd, 2007


MONDAY July 2nd, 2007

Meeting the Surrogate

People in the US who had been to India advised that the poverty and dirtiness would be horrible…but the experience would be great. We also expected to be mobbed by beggars and I expected to have a problem with the smaller personal spaces in this culture. But, we are happily not dealing with any of this! We are staying in a nicer part of the wealthiest city in India and it is shockingly easy;

The medical proceedings have been the difficult part. Today we went in for our visit, and also met our surrogate. Dr Parikh confirmed that there are still only two maturing follicles, and that the maximum number of eggs she expects is two. This compared to over 20 in younger women. Considering there are many steps left, each with its own probability, this leaves only a very small hope of success.

The meeting with our surrogate, Zuleka, was brief, but special. She doesn’t speak English, so Dr. Parikh translated the few questions that we had. She is 25 with two children of 9 and 6. Her husband is an electrician and supports her being a surrogate so long as she is comfortable with it. The country people in India have a very charming way of bobbing there head from side to side when things are ok, and she’s an expert at it. It’s the original bobblehead , and when done right, which she does, it’s as if the head is being controlled by a string. She seems like the shy country girl that Dr Parikh told us she is, and very charming.

Monday, July 2, 2007

JULY 1st, 2007


SUNDAY July 1st, 2007

Arrival to Bombay, 1st Doctor Visit and Backstory

We arrived at the Airport Saturday night without incident, and after retrieving our bags and changing a little money, we were met by the driver from the Hotel Shalimar who was waiting at exit with our name on a sign. On our way to the car a couple of freelance “carriers” did “help” us, and instead of the $5 they asked for, they begrudgingly received the 50 Rupees (Rs40, about $1), Hardy gave them. Our driver sped away through the wet streets- apparently the airport had been shut for a few hours earlier that day due to “waterlogging,” but one has to expect that if you come to Bombay in the monsoon season! Undeterred, our driver careened through the streets (he would do great in LA) at a speed too reckless even for me! Thank God he had a horn, which seemed to be a true part of the driving experience, as essential as the gas pedal. Mumbaikers use their horn to tell you they are behind you, are to the side of you, are about to pass you, think you should get out of the way, are going too slow- or anything, anything else. If the horn just started when you turned on the engine, that would probably be very agreeable to some drivers. As we left the Airport parking lot, I saw my first glimpse of the ubiquitous Bombay taxi, a tiny black and yellow vehicle, often wildly customized by the drivers fortunate enough to own their own one of the cars that troll Mumbai like an industrious ant colony, 65,000 strong.

30 perilous minutes later we arrived at the Shalimar Hotel, a stand-alone building nine stories high. Probably built in the late 60’s, it seemed to have a facelift six or seven years ago, and now featured a white marble lobby- with a water-wall. Our room is perfectly nice, and features floor to ceiling windows looking out onto Kemp’s Corner, a hodge-podge of colonial buildings which have seen better days, and once housed Salman Rushdie.

When we awoke this morning it was still raining, and we realized that even though we knew it was the rainy season, we hadn’t even brought an umbrella- stupid foreigners.
After we got up, we had the complimentary Continental Breakfast at the hotel in their very nice restaurant the Gulmurg, which seemed to feature items more from this continent than any other, but as I enjoy mango juice, chai (Masala) tea, fresh papaya and a mystery curry for breakfast, this was great for me.

We had an appointment with Dr. Parikh at 12noon, and Doris, the lovely concierge who I’d corresponded with over the internet, (and, of course, remembered as my Mother’s name is also Doris) called over to the Hospital to say we would be coming. After stopping for an umbrella-in the Taxi- we went over to Jaslok Hospital. The Taxi dropped us off across the street, and by the time we crossed two bodies of water that would be called streams in LA - we were completely soaked.

Jaslok Hospital also had a white marble lobby but probably from the 60s. In our research we had been led to believe that the Hospitals are as clean and new as in the States, but, as you can imagine, this wasn’t exactly what we saw. The lobby had a large wall with an old-fashioned Admissions area that was all varnished wood and hand-painted gold signage direct from the 30s. Alabaster busts of the foundered of the Hospital, wreathed with fresh flower necklaces, greet you at the stairs, and off to the side is an open marble temple with statues of several Hindu gods, with devotees praying and bringing gifts. Once past the lobby, we waited for the lift to the 8th floor, but after several minutes, decided to walk. This gave us a chance to check out the other floors, including a door that said Kidney Transplant Room, though it could also have been the office of a film noir detective.

When we got to the 8th Floor we were directed to Dr. Parikh’s offices which seem to be a Clinic within the Hospital. The rooms were older, but were given character by etched glass doors, and homey sofas. Although it was Sunday, there were still about ten patients waiting- about half with their husbands.

The great thing about IVF and reproductive clinics is that you can see anyone there. At this clinic (and in Beverly Hills with Dr Najmabadi who got our cycle started, and encouraged us in this trip) you can see people from all walks of life and all income and background levels. It is surprisingly comforting when you realize that infertility can be a challenge for anyone. Here in India, where family is such an essential part of life, and childlessness is not as accepted as in the States, I could see that Dr Parikh’s work is very important to so many. Some of the women in the in the waiting room wore elaborate Indian garb, and some were more western, but they all wore an expression of Hope, and they smiled that smile at us.

Soon we were directed to Dr Parikh’s office, a mix of Certificates, tchtchkees, plants-live and silk, Thank You notes and baby pictures. Dr. Parikh came in and greeted us warmly. We gave her the See’s candy we had brought ( my fav). Then we started the medical visit. First she answered all our questions. Yes, we were going to meet the surrogate- tomorrow at 5:30 pm. We were told she is a nice, caring woman with two children. Next, yes, they can do genetic testing before implantation, but more about that later. Then I went in the adjoining room (after peeing) and Dr Parikh gave me an ultra-sound.

A Little Backstory

As we glossed over in the intro to this blog, the whole reason we started looking into my reproductive health was that we wanted to start a family, and given my age (which of course I won’t reveal (43)) we thought we’d better get a move on. At the referral from my Gynecologist Dr Christine Collins at Cedars, we went to Dr Sam Najmabadi at the Center for Reproductive Health in Bev Hills. After many tests where Hardy scored in the 120%, and I was found to be somewhat challenged in my FSH (how much hormone needs to be sent to my ovaries to get a good egg- too much) and E2 (Estradoil, still not totally sure how this fits in). We decided there was no time like the present, and that we would pursue IVF, but there was just the little issue of whether or not a particular fibroid might need to be removed so as not to interfere with the pregnancy. It was in the Laproscopic surgery to explore this that Christine cut off some polyps inside the Uterus that were also in the way. And, as with everything they take out-they were sent to be biopsied. Imagine my shock when I received Christine’s early-morning call telling me I had Cancer. This started another saga that left me without a Uterus, but still with my Ovaries, and a chance to quickly find a surrogate and have a biological child. So, we went back to Dr. Najmabadi, who gave us information about agencies that would find a surrogate for us, and, me being me, I looked on the internet and went to Surrogate chat rooms, and followed leads graciously supplied by friends (thank you all). In the end, the total cost would be about $60,000 to $70,000- around $28,000 for the surrogate and costs (stipend and maternity), $20,000 for legal and agency fees, and the rest for the medical on my side and hers. We were told we had a five to ten percent success rate, due to my “old” eggs, which the age of the surrogate cannot change. Turns out egg age is paramount! What happened to having kids whenever you wanted, even into your 40’s?? I still laugh at the irony of spending so many years trying not to get pregnant, and now when I’d finally met someone with whom I really wanted to have a family, getting pregnant was literally impossible…almost!

It turns out that Surrogacy in America takes a lot of time and effort. The Surrogates, of course, wanted to get to know you and then set a time several months from then to meet and arrange a good time to be pregnant. And while we could make the money work, with a little discomfort, we simply didn’t have the time. As we later learned, I had become susceptible to the cancer because of a genetic condition called Lynch Syndrome. The type of Cancer my body is succeptible to is actually a Colorectal Cancer primarily, a Uterine Cancer secondarily, and lastly an Ovarian Cancer. This makes it important for me to have my ovaries removed sooner than later. The week I found out about my diagnosis, I was bemoaning the surrogate situation, when a Pakistani friend suggested we go to India, where she’d heard they were doing Surrogacy. What a crazy idea to fly half-way around the world! Well…maybe not! The cost savings- about $30,000 all in, would mean that we could try again if we failed the first time, and apparently there were many women there who would like the opportunity the money would give their families. When I first floated this idea on the Ether of my friends, they were worried that somehow we would get scammed. But the truth is that they only take women into the program who have children and a husband, for two reasons: first they have proved that they have had smooth, successful pregnancies, and second, with their own children and family, they are very unlikely to want to keep ours. The money that an Indian woman earns can send her child to college, or put a down-payment on a house. In addition, it is very unlikely that this woman will be drinking and smoking and driving- all the things I worried about most in a surrogate in America. We decided to do it! Assisted by the internet and my Aunt Tezi, our former Ambassador to Sri Lanka (Thank You so much!) we were able to get confirmation and guidance, and settled on Dr. Firuza Parikh at Jaslok, who had actually been named one of the 50 Most Influential Women in India, and is an occasional lecturer at Yale (she did 3yrs post-doc there). Once she had agreed to take our case, we decided to start on the June cycle, with Dr. Najmabadi’s guidance here at home. Unfortunately, in this cycle I developed a cyst (which we aspirated, but later bled into itself) and the Lupron made me develop another cyst- all of which prompted Dr. Naj to suggest we start looking for an Egg Donor. Trip cancelled on account of lack of follicles, the sites where eggs can grow. Low AFC (anterior follicle count), means low possible numbers of eggs. In the June cycle, not only did I have two cysts, but I only had an AFC of three.

Nevertheless with Dr Parikh’s encouragement, I started on birth control pills. When I had my last ultra-sound at Dr. Najmabadi’s on the 25th (last Monday), I will admit to having been pretty excited. I had no cysts, unlike in June when we had first tied to do this cycle. On top of that, I had eleven follicles!!!! I started taking the Menogon with high hopes of not only having eleven possible eggs, but maybe developing even more!!

Cut to Sunday- Dr Parikh’s Office

Dr Parikh took me into her examination room, so different from Dr. Najmabadi’s, but still featuring an ultrasound machine, or, as they would say Sonograph. Dr. Parikh searched for my Ovaries (which are hard to find given my lack of other parts). On the right ovary she found NO follicles, and on the left she found two large and two small.
What about the former eleven!? What about the elephantine doses of Menogon (essentially FSH- follicle stimulating hormone) that I was on??

Dr Parikh took us back into her office. I was devastated and confused. She explained that although you can start off with many follicles, your body then decides which to have go ahead and develop, and which should drop out. At present, I had only two follicles in the race, and two undecided. So that is the situation. Dr Parikh assured us not to be too discouraged, as, after all we only need one successful embryo to make a baby. Now we know this only too well.

Tomorrow we will meet the surrogate, and hope and pray for my two undecided follicles to decide in our favor.



Saturday, June 30, 2007

JUNE 31st, 2007


SATURDAY June 31st, 2007


LAX to BOM via Taipei and Kuala Lumpur

Sitting here at the ‘Cheers’ bar watching the Dodgers play San Diego drinking Carlsberg waiting for our flight Friday evening. Well, actually it’s Saturday afternoon and we’re in Kuala Lumpur! How ironic to walk into the bar and see the Dodgers on TV! Not many places to get a beer here at the airport in a Muslim country, but we thought it was well deserved after 20hrs of travel.
Before KL, we arrived to Taipei at 6:40AM Saturday. We got of the plane and had to circle back through security. Passed some shops, Duty Free, that type of thing. Nothing too interesting, except that I did have a pretty good baguette stuffed with ham and cheese which really hit the spot with a Coke. The Coke actually said iCoke on it, I guess the ‘i’ rage is worldwide. Speaking of ‘i’ we stopped at a bunch of tables that said wireless connection and got the computer out only to realize that they only had dial-up. I don’t think my computer even has a pone jack in it.
The arrival into Taipei was pretty. Lot’s of green and huge frangipanis outside the airport windows. No piece of land is unused – rice paddies pop up between car lots, industrial building and railroads, making LA look very brown and dirty in contrast. Arrival to KL was different, though still lush. Less density and more sprawl/haphazard development in KL; Taipei actually looked like it had good planning. In KL instead of rice it was palm trees—miles and miles; very pretty.
Started out from home Thursday night at 11: PM on the FlyAway bus from Union Station to LAX. Just gave Regina her shot, and we used the intramuscular needle for the first time tonight. It’s longer and scarier looking than the sub-coetaneous needle, which is the same as the little needle used for insulin injections. But, somehow it was also less painful, and that’s good, because the injections have been painful until now.
There was a little spat between the doctors today. Well, not so much of a spat but we were getting different information. I guess it’s our fault for having duplicate doctors, but that’s what happens when you’re being treated in two hemispheres! The medication we are taking now is called Menogon and the instructions say to take it with an intramuscular needle. Our Beverly Hills doctor gave us subcutaneous needles, and after about a day we realized this and emailed Dr. Parikh in Bombay to ask if it was a problem. We were pretty stressed about this, because if it did happen to be a problem, we were scared that our trip this month would be cancelled! She said it should be OK, but that we should take it IM. At 10PM last night we were ready to take the shot, but not sure what to do. Regina considered going to the ER to get IM needles, but instead she called her friend Chris Cassidy in Houston and he said it should be ok, so we took it with the sub-cue needle.
We also called my friend Dr. David Kauffman in Ft. Lauderdale, but he didn’t answer because it was 1AM! Coffee (Kauffman). But he called back and helped us out a lot by writing a letter to let us take the needles and vials on the plane, though in the end we didn’t get checked.
If we were doing the treatment entirely here in LA, we would be taking Repronex. Menogon is the European version of Repronex, and we got it on ivfmeds.com and had it shipped from London for half the cost of buying it here in the US – more internet power.



Friday, June 29, 2007

Outsource our niece or nephew!

We are super excited for you! Sorry that you can't join us in Portland and the Coast but we are so happy this is finally coming to fruition. Thanks for the blog - we'll be checking in!

Love, Marisa and Brandon